Discipline - Biophysics
- List of academic staff
- Useful information for students
- 5-10 key words that describe subdomains of interest for the research activities
- 5 of the most representative research projects completed
- The most significant 10 scientific theses
Professor | Baran Irina-Elena, PhD | tenured |
Associate Professor | Ionescu Diana, PhD | tenured |
Associate Professor | Iftime Adrian-Marius, PhD | tenured |
Associate Professor | Calinescu Octavian, PhD | tenured |
Lecturer | Babes Ramona Madalina, PhD | tenured |
Assistant Professor | Nisiparu Luciana, PhD | tenured |
Assistant Professor | Iordache Maria-Minodora, PhD | tenured |
Assistant Professor | Barca Valentin, PhD | tenured |
Assistant Professor | Gatin Gheorghe-Eduard, PhD | tenured |
Assistant Professor | Calin Violeta Liuba, PhD | tenured |
Assistant Professor | Calugaru Laura-Lidia, PhD | tenured |
The Medical Biophysics Course is destined to first-year General Medicine students and takes place over one semester; it comprises a 2-hour course and an 3-hour practical course per week.
The course is valued at 4 credits.
Information about how the course takes place (subjects, bibliography, organization, exams) for students of each series can be found on the Medical Biophysics discipline page.
Within the Medical Biophysics discipline, students are co-opted into research projects and graduates into graduate programs.
Current research directions of the Discipline:
- the study of some chemical and physical factors’s effects on cell proliferation
- the study of the celular and membranar effects of polyphenols (quercetin, epigallocatehin gallate), pf menadione, doxorubicin and that of mitochondrial respiration inhibitors (rotenone, antimycin A) using spectrofluorometric AYand flow cytometry methods.
- calcium cellular signals monitoring ; calcium channel ryanodine receptor and inositol triphosphate receptor activity, molecular mechanisms to regulate the receptor’s activity ;
- determining the cell’s viability, its apoptotic/necrotic fraction, its cell cycle phases distribution, its intracelullar calcium concentration, its mitochondrial depolarization degree, or its oxidative stress degree using fluorescent indicators in spectrofluoriometry or flow cytometry;
- mathematical modelling of the enzymatic mechanisms which regulate the cell cycle
- investigarea proteinelor membranare de transport prin electrofiziologia bazat�f pe membrane pe suport solid (SSM)
- studies of the electrical and mechanical properties of artificial lipid membranes in various conditions using BLM/SSMmethods
- cell studies using the patch-clamp method
- visual psychophysics
- some chemical and physical factors’s effects on cell proliferation
- polyphenols’s celular and membranar effects
- calcium cellular signals
- electrophysiology based on patch-clamp, solid supported membrane (SSM), and black lipid membranes (BLM)
- human visual psychophysics
- spectrofluorometry
- flow cytometry
Over the years, within the Medical Biophysics discipline many research projects were completed (see Biophysics/Research), among which:
- PNII-IDEI-PCE-2011-3-0800, nr. 342/2011: Studiul mecanismelor moleculare si celulare ale actiunii EGCG si quercetinei ca potentiali agenti chemoterapeutici pentru celulele leucemice umane Jurkat T (Director Prof. C. Ganea) – în desfăşurare
- PN-II-RU-TE-2014-4-0604: Caracterizarea funcţională şi farmacologică a sistemelor de antiport Na+/H+din Klebsiella pneumoniae(Director Ș. L. O. Călinescu) – în desfăşurare
- PN-II-RU-TE-2011-3-0204, nr. 111/10.10.2011 Efectul polifenolilor in modularea relatiei dintre proteinele ErbB si ciclul celular in progresia adenocarcinomului mamar si epidermoid (Director Conf. M. M. Mocanu)
- 4. PN II – IDEI 1138 / 2009, Mecanisme complexe de semnalizare celulară prin intermediul ionilor de calciu în condiţii normale sau de stress oxidativ – rolul în proliferare, apoptoză şi în cuplajul excitaţie/contracţie musculară (Director Prof. I.Băran)
- CEEX 74/2006 Efectele celulare şi subcelulare ale unor antioxidanţi naturali în condiţii normale şi de stress(Director Prof. C. Ganea)
- Tofolean IT, Ganea C, Ionescu D, Filippi A, Garaiman A, Goicea A, Gaman MA, Dimancea A and Baran I, Cellular determinants involving mitochondrial dysfunction, oxidative stress and apoptosis correlate with the synergic cytotoxicity of epigallocatechin-3-gallate and menadione in human leukemia Jurkat T cells,PHARMACOLOGICAL RESEARCH103: 300-317 (if 4.408)(2016)
- Iftime A, Ganea C, Popescu Rightmire A, Interference of coumarin with the insertion of lyotropic anions and cadmium in artificial lipid bilayers,ROMANIAN BIOTECHNOLOGICAL LETTERS 20(4): 10637-10647 (if 0.404) (2015)
- Baran I, Ionescu D,Filippi A, Mocanu MM, Iftime A, Babes R, Tofolean IT, Irimia R, Goicea A, Popescu V, Dimancea A, Neagu A and Ganea C,Novel insights into the antiproliferative effects and synergism of quercetin and menadione in human leukemia Jurkat T cells, Leukemia Research38(7): 836-849 (if 2.692) articol premiat la competiţia PN-II-RU-PRECISI-2014-8 (UEFISCDI); articol distins de editura canadiana Global Medical Discovery la sectiunea Key Scientific Article (2014)
- Mocanu MM, Ganea C,Georgescu L,Varadi T, Shrestha D, Baran I, Katona E, Nagy P, Szöllösi J, Epigallocatechin-gallate determines ErbB proteins downregulation, cell death mediated by 67kDa laminin receptor and altered lipid order in mammary and epidermoid carcinoma cells, JOURNAL OF NATURAL PRODUCTS 77 (2):250–257 (if 3.285) (2014)
- Baran I, Ionescu D, Privitera S,Scordino A, Mocanu MM, Musumeci F, Grasso R, Gulino M, Iftime A, Tofolean IT, Garaiman A, Goicea A, Irimia R, Dimancea A and Ganea C,Mitochondrial respiratory Complex I probed by delayed luminescence spectroscopy, Journal of Biomedical Optics18(12):127006 (if 3.145) – articol premiat PN-II-RU-PRECISI-2014-8 (UEFISCDI) (2013)
- Baran I, Katona E, Ganea C,Quercetin as a fluorescent probe for the Ryanodine receptor activity in Jurkat cells, PFLUEGERS ARCHIV, EUROPEAN JOURNAL OF PHYSIOLOGY 465(8): 1101-1119. (IF 4.866) (2013)
- Ionescu D, Margină D, Ilie M, Iftime M and Ganea C,Quercetin and epigallocatechin-3-gallate effect on the anisotropy of model membranes with cholesterol, Food and Chemical Toxicology61:94-100, (if 3) articol premiat PN-II-RU-PRECISI-2014-8 (UEFISCDI) (2013)
- Baran I and Ganea C,RyR3 in situ regulation by Ca2+ and quercetin and the RyR3-mediated Ca2+ release flux in intact Jurkat cells, ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 540: 145–159 (if 3.043) (2013)
- Ionescu D and Ganea C,A study of quercetin effects on phospholipid membranes containing cholesterol using Laurdan fluorescence, EUROPEAN BIOPHYSICS JOURNAL41:307–318, ISSN 0175-7571 (if 2.387) – articol premiat PN-II-RU-PRECISI-2012-6 (UEFISCDI) (2012)
- Baran I, Ganea C, Scordino A, Musumeci F, Barresi V, Tudisco S, Privitera S, Grasso R, Condorelli DF, Ursu I, Baran V, Katona E, Mocanu MM, Gulino M, Ungureanu R, Surcel M, Ursaciuc C, Effects of menadione, hydrogen peroxide and quercetin on apoptosis and delayed luminescence of human leukemia Jurkat T-cells. CELL BIOCHEMISTRY AND BIOPHYSICS 58: 169-179 (if 1.68) – articol premiat PN-II-RU-PRECISI-2010 (UEFISCDI) (2010)