Discipline -
- List of academic staff
- Description of medical activity
- Useful information for students
- 5-10 keywords which describes the subfields of interest for the research activity
- 5 representative ongoing reseach projects
- Up to 10 most representative scientific papers
The Biochemistry discipline conducts the following activities for education and research:
- Biochemistry course for students of the Faculty of Midwifes and Nursing, specializations: general nursing, Midwifes, dental technique and balneofiziokinetotherapy (Year I)
- Clinical Biochemistry course for students of the School of Midwifes and Nursing, specialization general nurse (III year) (optional course)
- Practical applications of medical biochemistry for students of the School of Midwifes and Nursing,specializations: general nursing, Midwifes, dental technique and balneofiziokinetotherapy (Year I)
- Guidance for license
- Guidance for dissertation
- Implementing research projects
The biochemistry course aims to make students acquire knowledge on the main types of biochemical compounds, their distribution and importance, developing the ability to correlate with the aspects of the structural biochemistry with those of functional biochemistry.
The practical applications aims to familiarize students with laboratory techniques and working knowledge of operating specific devices and the correct application of methods of analysis of the main biochemical compounds.
Research projects implemented within the discipline are centered on the study of inflammatory and oxidative stress markers in various pathologies.
Specializations
- General Nursing
- Midwifes
- Balneofiziokinetotherapy
- Dental Technique
Biochemistry Course Syllabus – GN AND BFKT (2 hrs/week)
- Object of biochemistry. Correlation of biochemistry with other biomedical sciences. natural amino acids
- Peptides. Major natural peptides (glutathione). Protein. plasma proteins
- Hemoprotein (myoglobin and hemoglobin)
- Immunoglobulins and fibrinogen
- Collagen and elastin
- Enzymes
- Biochemistry hormones
- Thyroid hormones. Pancreatic hormones. Hormones that regulate calcium homeostasis: adrenal medullary hormones. adrenocortical hormones
- Oxidative Metabolism. Macroergic compounds. Basal metabolic rate
- Carbohydrates: monosaccharides, oligosaccharides, polysaccharides
- Digestion and absorption of carbohydrates. Carbohydrate metabolism.
- Fats. Fatty acids saturated and unsaturated
- Lipid metabolism
- Plasma Lipoprotein
- Elements of gene therapy
Biochemistry Course Syllabus – Midwifes (2 hrs/week)
- Object of biochemistry. Correlation of biochemistry with other biomedical sciences. natural amino acids
- Peptides. Major natural peptides (glutathione). Protein. plasma proteins
- Hemoprotein (myoglobin and hemoglobin)
- Immunoglobulins and fibrinogen
- Collagen and elastin
- Enzymes
- Biochemistry hormones. Thyroid hormones. Pancreatic hormones. Hormones that regulate calcium homeostasis: adrenal medullary hormones. adrenocortical hormones
- Sinthesys of hormones in pregnancy. Placenta: endocrine organ
- Oxidative Metabolism. Macroergic compounds. Basal metabolic rate
- Carbohydrates. Digestion and absorption of sugars.
- Carbohydrate metabolism. Changes in glucidic metabolism in pregnancy
- Fats. Fatty acids saturated and unsaturated. The role of lipids in pregnancy.
- Lipid metabolism. Changes in lipid metabolism in pregnancy
- Plasma Lipoprotein
- Correlation between intermediary metabolism
- Homeostasis gravidarum
- Specialization of metabolic tissues and organs in pregnancy
Biochemistry Course Syllabus – Dental Technique (2 hrs/week)
- Object of biochemistry. Correlation of biochemistry with other biomedical sciences. natural amino acids
- Peptides. Major natural peptides (glutathione). Protein. plasma proteins
- Hemoprotein (myoglobin and hemoglobin)
- Immunoglobulins and fibrinogen
- Collagen and elastin
- Enzymes
- Biochemistry of hormones. Thyroid hormones. Pancreatic hormones. The hormone that regulates calcium homeostasis: adrenal medullary hormones. adrenocortical hormones
- Carbohydrates. General ways of transforming carbohydrates.
- Fats. Fatty acids saturated and unsaturated. Metabolism of lipids, plasma lipoproteins.
- Mechanisms taste. Taste bud. Gustatory sensations. Gustatory sensory cell. Tastes: salty, sour, sweet, bitter and umami. Adapting taste.
- Biochemistry of saliva. Structural issues. The composition and properties of saliva. Factors influencing the composition of saliva. Saliva functions. The role of saliva in taste sensitivity.
- The chemical composition of teeth. Organic and inorganic components of the tooth structure.
- Hydroxyapatite. Hydroxyapatite role in the composition of dental structures.
- Decay. Compounds acting carioprotectoare
- Biochemistry of oral cavity. Biochemical processes in dental plaque
- Bacterial adhesion. Dental plaque.
- Relationship of peroxidase human salivary system with oral health. Oxidative stress in oral pathology.
- Adherence to the hard dental tissues. Factors influencing the integrity of the oral structures.
- Fluoride: features, biochemical function
- Biochemistry materials used in the dental laboratory.
- Restorative coronary. Dental amalgams. Materials for prostheses.
- Dental alloys. Porcelains.
Recommended bibliography for the theoretical exam:
- Biochimie Medicala. Valeriu Atanasiu, Ed. Universitara "Carol Davila", BucureAYti, 2008.
- Biochimie Medicala. Maria Mohora, Ed Niculescu 2006.
- Biochimie Medicala - Mic tratat. V. Dinu, E. Trutia, E. Cristea, A. Popescu, Ed. Medicala 2000.
- Harper's Biochemisty. Ed. Appleton & Lange, 1990.
- Biochimie Medicala – Teste grila pentru facultatea de moaAYe. Coordonatori: Valeriu Atanasiu, Irina Stoian; Autori: Laura Gaman, Bogdan Manolescu, Daniela Lixandru, Carmina BuAYu, Elena Panait; Editura Universitara "Carol Davila", BucureAYti, 2008 (ISBN: 978-973- 708-321- 0)
- Biochimia cavitatii orale, Maria Greabu, Editura Tehnica, Bucuresti, 2001
- Biochimia cavitatii orale (Editia a II-a revizuita si adaugita), Maria Greabu, Editura Standardizarea, Bucuresti, 2012- 2015
- Biochimie pentru colegiul de tehnica dentara. Maria Greabu, Alexandra Totan, Editura Standardizarea, Bucuresti, 2010
Current research directions of Biochemistry Discipline:
- Studies on oxidative stress markers in patients with type 2 diabetes newly diagnosed or associating various complications (neuropathy, nephropathy, hypertension, atherosclerosis)
- Studies on inflammatory process associated with obesity and type 2 diabetes
- Studies on basal metabolic rate
- Studies on cutaneous neurogenic inflammation in the diagnosis of diabetic neuropathy
- Studies on the impact of metabolic surgery in patients with type 2 diabetes and obesity
- Studies on pancreatic beta cell lines on the synthesis and secretion of insulin
- Studies on the relationship between adipose tissue and tumor progression
- Evaluation of skin microvascular confocal microscopy in human subjects
- Iinflammatory skin diseases, skin cancers
- diabetes mellitus
- inflammatory process
- oxidative stress
- body fat
- obesity
- adipokines
- metabolic surgery
- cancer
- 2014 - ongoing - Project Partnerships in Priority Areas PN-II- PT-PCCA- 2013-4- 2154; Developing a protocol selection for metabolic surgery following an evaluation of its impact on remission of type 2 diabetes patients obese "no. 207/2014 (the Contracting Authority: Executive Unit for Financing Higher Education, Research, Development and Innovation); Acronym credit (Collaborative Efforts for Diabetes and Obesity Romanian Research) project site: www.credor.ro
- 2011 - 2016 - Project Ideas - Exploratory Research Projects PN-II- ID-PCE- 2011-3- 0429 entitled Adipose tissue at the crossroads pathogenesis of diabetic vascular disease", No. 183 / 28.10.2011 (Authority contracting: Executive Unit for Financing Higher Education, Research, Development and Innovation) project site www.paulescu.ro
- REFLECTANCE CONFOCAL MICROSCOPY AND DERMOSCOPY FOR IN VIVO, NON-INVASIVE SKIN IMAGING OF SUPERFICIAL BASAL CELL CARCINOMA Ghita MA, Caruntu C, Rosca AE, Kaleshi H, Caruntu A, Moraru L, Docea AO, Zurac S, Boda D, Neagu M, Spandidos DA, Tsatsakis AM. Oncol Lett. 2016 May;11(5):3019-3024 (factor de impact 1.554)
- VARIATIONS IN THE EXPRESSION OF TIMP1, TIMP2 AND TIMP3 IN CUTANEOUS MELANOMA WITH REGRESSION AND THEIR POSSIBLE FUNCTION AS PROGNOSTIC PREDICTORS Zurac S, Neagu M, Constantin C, Cioplea M, Nedelcu R, Bastian A, Popp C, Nichita L, Andrei R, Tebeica T, Tanase C, Chitu V, Caruntu C, Ghita M, Popescu C, Boda D, Mastalier B, Maru N, Daha C, Andreescu B, Marinescu I, Rebosapca A, Staniceanu F, Negroiu G, Ion DA, Nikitovic D, Tzanakakis GN, Spandidos DA, Tsatsakis AM. Oncol Lett. 2016 May;11(5):3354-3360 (factor de impact 1.554)
- NEGATIVE ASSOCIATION BETWEEN PARAOXONASE 2, ANTHROPOMETRIC MARKERS AND METABOLIC SYNDROMEAndrada Mihai, Daniela Lixandru, Petruţa Alexandru, Irina Stoian, Simona Carniciu, Manuela Mitu, Cristian Guja, Constantin Ionescu-Tîrgovişte Open Life Sci. 10, 365-371, 2015 (factor de impact =0.710)
- CHANGES IN THE SERUM PROINFLAMMATORY CYTOKINES IN PATIENTS WITH ELEVATED HOMA-IR AND TYPE 2 DIABETES MELLITUS Daniela Lixandru, Elena Violeta Băcanu, Bogdana Vîrgolici, Horia Vîrgolici, Alexandru Petruţa, Marius Emil Băcanu, Paul Gagniuc, Constantin Ionescu-Tîrgovişte, Cristian Serafinceanu Farmacia, vol 63 (1), pp. 132 -139, 2015 (factor de impact = 1.251)
- ERYTHROCYTE MEMBRANE STABILITY TO HYDROGEN PEROXIDE IS DECREASED IN ALZHEIMER’S DISEASE Gilca M, Lixandru D, Gaman L, Vîrgolici B, Atanasiu V, Stoian I. Alzheimer Dis. Assoc. Disord., Oct-Dec; 28(4):358-63.doi: 10.1097/WAD.0000000000000026. 2014 (factor de impact = 2.728)
- ESTIMATING THE YIN-YANG NATURE OF WESTERN HERBS: A POTENTIAL TOOL BASED ON ANTIOXIDATION- OXIDATION THEORY Gilca M, Gaman L, Lixandru D, Stoian I. Afr J Tradit Complement Altern Med 11 (3): 210-216. 2014 (factor de impact = 52)
- DOES DIALYSIS MODALITY INFLUENCE THE OXIDATIVE STRESS OF UREMIC PATIENTS Capusa C, Stoian I, Rus E, Lixandru D,Barbulescu C, Mircescu G.Kidney Blood Press Res; 35: pp 220-225; 2012 (DOI: 10.1159/000331560) (factor de impact = 1.464)
- CORRELATIONS BETWEEN OBESITY ANTROPOMETRIC MARKERS, ADIPOCYTOKINES AND MONOCYTES OXIDATIVE STRESS STATUS IN TYPE 2 DIABETIC PATIENS Elena Violeta Bacanu, Daniela Lixandru, Irina Stoian, Bogdana Virgolici, Maria Mohora, Niculina Mitrea, Constantin Ionescu-Tirgoviste Farmacia, vol 60 (1), pp -21-32, 2012 (factor de impact = 1.251)
- DIET AND PARAOXONASE 1 ENZYMATIC ACTIVITY IN DIABETIC FOOD PATIENTS FROM ROMANIA AND BELGIUM: FAVOURABLE ASSOCIATION OF HIGH FLAVONOID DIETARY INTAKES AND ARYLESTERASE ACTIVITY Daniela Lixandru,Maria Mohora, Anca Coman, Irina Stoian, Carolien Van Gils, Petra Aerts, Begona Manuel-y-Keenoy Annals of Nutrition and Metabolism, vol 56, no 4, pp 294-301, 2010 (factor de impact = 2.461)
- ANTIOXIDANT DEFENCE CAPACITY IN SCLERODERMA PATIENTS Sfrent-Cornateanu R, Mihai C, Stoian I, Lixandru D, Bara C, Moldoveanu E.Clin Chem Lab Med.; 46(6): pp 836-41. PMID: 18601607; 2008 (factor de impact = 2.150)
