Discipline - Genetics

Professor Severin Emilia-Maria-Margarita, PhD tenured
Associate Professor Albu Cristina-Crenguta, PhD tenured

At the beginning of the '90s, the Biology-Genetics discipline got separated from the common trunk of the Medical Biology that wa taught to the students in the 2nd year of the Faculty of Medicine, Pediactrics and Dentistry, becoming an autonomous discipline within the Faculty of Dental Medicine. Within this context, the change of the name and of the academic curricula was imposed.  The whole didactic and scientific activity of the discipline has armonized theoretically and practically with the dental medical profile of the Faculty. As a biomedical discipline, in conformity with the Norm CE 36/ 2005, annex V.3. Dental Practitioner subparagraph 5.3.1.A, baseline domains, Biology-Genetics, together with Chemistry and Physics, is included in the category of baseline disciplines.

In 2004, professor Francis Collins, director of the National Institutes of Health (Bethesda, Maryland, U.S.A), was making a call for all academic communities around the world ( A Call for Increased Education in Genetics for Dental Health Professionals, J Dent Educ., 2004: 68(8): 807-808) pointing out that in the post-genomic era "genomic tests will be the basis of the whole medicine".

Development of the advanced biotechnologies will accelerate the gradual transformation of the classical medicine's concepts through using predictive and individual susceptibility to illness  tests, customization of medical investigations, of diagnostics and of treatments offered to the patient. The individual approach of each patient as ill and not as a generic illness is the result of applying genomics in the clinical practice.

Integrating the genetics and genomics knowledge in the medical practice needs doctors trained to understand and apply genomic medicine. Because of these reasons, in the dental medical education is needed a new set of genomic knowledge, specific terms, abilities and atitudes towards genomic technologies, so that the future generations of practitioners would be able to apply the results of the genetic tests in the clinical practice (Covic M., 2011).

These are only a few arguments from which we can observe that the discipline of Biology-Genetics, as a fundamental and applied discipline, cannot be absent from the modern medical education system.

"Knowing is not enough, knowledge has to be applied" (Leonardo da Vinci)

The dentistry students are prepared to understand the impact of genetic modifications on the oral health, to recognize oro-dental anomalies and syndromic and non-syndromic craniofacial dysmorphisms, to know the causes and pathogenesis of a anomaly or illness that affects the craniofacial complex, to be informed about the available genetic tests that offer them the posibility of knowing the genetic profile and the profile of the risk factors of a patient.

Thus, the future dentistry physician will be able to integrate in a multidisciplinary team and will be able to apply in his medical practice the concepts and principles of the precision medicine: prediction, prevention, personalization and participation. Personalization of the patient's therapy, teaching and involvement of the patient in the therapeutic and recuperative process, are the ways to succeed in confronting the imense clinical and genetic variability of the oro-dental anomalies that cause the patient's depreciation of the quality of his life and emotional discomfort.

"From the patient's bed in the research laboratory and from the research laboratory to the patient's bed" (translational medicine)

World Health Organisation (WHO), The International Association for Dental Research (IADR) as well as other international organizations proposed an oral health program that includes also the research in the field of oro-dental anomalies (Promoting Oral Health in the 21st Century, WCPD – The Liverpool Declaration 2005).

The students' research projects carried out during their preparing for the elaboration of their graduation papers follow the stimulation of scientific curiosity and the development of thier research abilities of the future dental physicians. The medical dentistry profession is done mainly in the clinic and not in the research field. The dentistry physician can offer observations and clinical data essential for laboratory research whose results are returning to the clinic.

  • Carnio-facial dysmorphisms and oro-dental anomalies determined or influenced genetically.
  • Study of biological activity and mechanism of action of potential antiproliferative drugs – University of Padua, Italy. 2001 – 2005.
  • Molecular Investigations of Pax9 gene mutations involved in tooth agenesis (Viasan 390). 2004-2006
  • Surditatea non-sindromică la copil: diagnostic clinic şi molecular (PNCDII 42-143). 2008-2011
  • International Dental Research Project for students ”Common, Rare and Individual Oro-Dental Findings in Down Syndrome”. 2011
  • Mixed-Ligand Copper(I) Complexes: Role of Dimine Ligands on Cytoxicity and Genotoxicity – University of Padua, Italy. 2011 – 2014
  • Can a mixed damage interfere with DNA-protein cross-links repair ? Christine Marzano, Emilia Severin, F.Bordin – J Cell Mol Medicine, vol.5, 2, 2001, ISSN 1582-1838 (print), PMID: 12067500 [PubMed – indexed for MEDLINE]
  • Developmental failure of one or more teeth in families –Emilia Severin, Crenguta Albu, D.Albu, Ileana Ioachin, Arina Vinereanu, D.Stanciu, International Poster Journal of Dentistry and Oral Medicine, Vol. 11, No 1, March 15th, 2009, ISSN 1612-7749.
  • Meziodensul familial – Emilia Severin, Razvan Purcarea, Crenguta Albu, Dinu F.Albu, Ecaterina Ionescu, Dragos Stanciu, Revista Romana de Stomatologie Volumul LV, Nr.4, pg.293-296, 2009, ISSN 1843-0805.
  • Prenatal Screening for the 35delG GJB2, Del(GJB6-D13S1830), and Del(GJB6-D13S1854) Mutations in Romanian Population – Cristina Dragomir, Adriana Stan, Dragos T. Stefanescu, Lorand Savu, and Emilia Severin. Genetic Testing and Molecular Biomarkers,15(11): 749-753, 2011. ISSN 1945-0265, eISSN 1945-0257.
  • Identical mutation in SH3BP2 gene causes clinical phenotypes with different severity in mother and daughter – case report – L.Preda, O.Dinca, A. Bucur, Cristina Dragomir, Emilia Severin, Molecular Syndromology, 2010; 1: 87-90, ISSN 1661-8769 (print). DOI:10.1159/000314268, 2010,PMID: 21045962 [PubMed]
  • Novel Mixed-Ligand Copper(I) Complexes: Role of Dimine Ligands on Cytotoxicity and Genotoxicity – Valentina Gandin, Marina Porchia, Francesco Tisato, Alessandro Zanella, Emilia Severin, Alessandro Dolmella, Cristina Marzano, Journal of Medicinal Chemistry, 56(18): 7416-7430, 2013. Print ISSN 0022-2623, eISSN 1520-4804.
  • Cherubism: a case report – Octavian Dincă, Emilia Severin, Cristian Vlădan, Dana Cristina Bodnar, Alexandru Bucur, Romanian Journal of Morphology and Embryology, 2014, 55 (2 Suppl): 3-6, 2014. ISSN (print) 1220-0522.
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