Discipline - Hematology (Clinic and Laboratory) - Coltea Clinical Hospital

Professor Colita Andrei, PhD tenured
Associate Professor Berbec Nicoleta Mariana, PhD tenured
Head of works Angelescu Silvana, PhD tenured
Head of works Stanca Oana, PhD tenured
Head of works Saguna Carmen, PhD tenured
Assistant Professor Triantafyllidis Irina-Nicoleta, PhD tenured
Assistant Professor Popovici Constanta-Elena, PhD tenured
Assistant Professor Negotei Cristina, PhD fixed term
Assistant Professor Lapadat Mihai-Emilian, PhD fixed term
Assistant Professor Turbatu Andrei, PhD tenured
Assistant Professor Barta Cristian Tudor, PhD fixed term

Coltea Hematology Clinic is the youngest clinic of the oldest hospital in Bucharest. Hematology Clinic was founded in Coltea Hospital in 1993. Teaching started with a nucleus of young doctors under the leading of Professor Delia Mut Popescu MD, experienced a continuous and intense development, diversification and improvement of teaching methodology, exacerbating practical training for future specialists.

For continuing training of young medics (students, residents) teaching materials were developed, along with numerous scientific papers, promoting new concepts in hematologic thinking, systems analysis and monitoring of patients after the example of the most renowned clinics and laboratories world, placing the Department of Hematology of Hospital Coltea valued at the University of Medicine and Pharmacy "Carol Davila". Professor Anca Roxana Lupu  MD (born 1954) leading the discipline since 2004, graduated as valedictorian in 1970 the  Faculty of Medicine and Pharmacy in Bucharest being Doctor in Medical Sciences in 1996. Primary Physician in Internal Medicine (1990) and Clinical Hematology (1998). She is the president of the Romanian Society of Hematology and Vice President of the Romanian Society of Haemostasis.

In Hematology Clinic of Hospital Coltea patients suffering from diseases of all hematologic pathology field are cured. However, the most common pathology is that of haematological malignancies (acute and chronic leukemias, lymphoproliferative syndromes, myeloproliferative, myelodysplasias).

The clinic has a capacity of 50 beds for continuous hospitalizations and a day care sector. Since 2014 the Clinic operates a Department of Bone Marrow Transplantation, 5 beds, where they performed procedures such as hematopoietic stem cell transplantation for patients with hematologic malignancies. Also in the Coltea Hospital Hematology Clinic and Hematology Laboratory investigations, morphology and cytochemistry, immunophenotypings, hemostasis, immunology, cytogenetics and molecular biology are performed.

In the Department of Clinical Hematology Coltea run hematology courses and internships according to the syllabus for students in the sixth year of UMPh Carol Davila. The practical activity for students includes the presentation of clinical cases and visits to the patients hospitalized in the Hematology Clinic and laboratory practical work (morphology and haemostasis). It also runs a number of optional courses for students in years IV-VI. An important activity is research in order to elaborate bachelor degrees.

Besides the activities of medical students education the clinic is developing theoretical (classroom, present case presentations of data from the literature) and practical activities (clinical activity and laboratory) for residents in specialties of clinical hematology, laboratory medicine, internal medicine, oncology, infectious diseases, gastroenterology.

The clinic also teaches postgraduate training courses for specialists and primary physicians in various specialties.

Special attention is given to doctoral studies, currently being underway 6 PhD themes under the leading of Professor Anca Roxana Lupu MD.

The team of the department is actively involved in educational projects of UMPh Carol Davila, Romanian Society of Hematology, the Romanian Society of Thrombosis and Haemostasis, College of Doctors through constant participation with papers, courses, lectures.

In terms of research, the discipline team has sustained activities in multiple projects involving medical research, postdoctoral projects and clinical trials. The research results are the participation and presenting of scientific papers at national and international professional events and publishing articles in magazines of hematology laboratory in Romania and abroad in ISI or other BDI.

Syllabus- Hematology – 6th Year

Course topics - 2h/day, 5 days/week

  1. Hematopoiesis - hematopoietic cell series
  2. Hypochromic microcytic anemia - hyposideremic. Simple chronic anemia
  3. Macromegaloblastic anemia
  4. Hereditary hemolytic anemia
  5. Acquired haemolytic anemia
  6. Acute Leukemia
  7. Chronic Myeloid Leukemia
  8. Chronic myeloproliferative neoplasms
  9. Chronic lymphatic leukemia
  10. Hodgkin's disease
  11. Malignant non-Hodgkin's lymphoma
  12. Multiple myeloma
  13. Other malignant monoclonal gammopathies
  14. Bleedings of vascular cause (vasculopathy), and of platelet cause (trombopatii)
  15. Bleedings of plasma cause (coagulopathy: hereditary and acquired)

Practical work - 4h/day, 5 days/week

  1. Medical anamnesis, physical examination of the patient's. Hematological observational sheet features
  2. Presentation of clinical cases of hematologic malignant and benign pathologies
  3. Diagnostic significance of blood count, interpretation
  4. Microscopy - marrow cell series
  5. Microscopy - blood cells
  6. Microscopy - pathological erythrocytes, leukocytes, platelets
  7. Laboratory probes: coagulation screening
  8. Laboratory probes diagnoses coagulopathy, trombopatii
  9. Other laboratory investigations with diagnostic significance over hematologic disorders
  10. Diagnostical methods specific to the specialty - punctures, bone biopsies - illustrations
  11. Specific therapy methods - practical examples

 Evaluation - Written exam

BIBLIOGRAPHY :

"Patologia Hematologica" "Hematology pathology". Under the redaction of Professor Anca Roxana Lupu MD. University Publoishing House Carol Davila 2007, 169 pag.

"Hematologie clinica" „Clinical hematology„ -Professor Delia Mut Popescu MD. ─ 2nd Edition . - Bucharest : Medical Publishing House, 2003 (Universul) 336 pag. - (Courses ).2004/28a.

  • DIAGNOSIS AND EVALUATION OF THERAPEUTICAL RESPONSES IN ACUTE LEUKEMIA
  • DIFFERENTIAL DIAGNOSIS: LEUCEMOIDA AND LEUCOCYTIC REACTION
  • HYPOCHROMIC ANAEMIAS. POSITIVE DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS
  • BLEEDING SYNDROME - LABORATORY AND CLINIC DIAGNOSIS
  • HEREDITARY AND ACQUIRED THROMBOPHILIA
  • STAGES IN PARACLINICAL DIAGNOSIS OF HAEMOLYTIC ANEMIA
  1. Iron metabolism; methods of investigation.
  2. Megakaryocyte series; study methods of platelets.
  3. Lymphocytic series: study methods.
  4. Haemostasis and fribrinolysis: exploration in the clinic.
  5. Transfusion of blood cell concentrates: principles, indications, counterindications, accidents.
  6. Aplastic Anemia.
  7. Hypochromic anemias.
  8. Hemolytic anemias.
  9. Megaloblastic anemias.
  10. Chronic myeloproliferative syndrome.
  11. Myelodysplastic syndrome.
  12. Acute leukemias.
  13. Chronic lymphocytic leukemia: common form of leukemia and chronic lymphocytic variants.
  14. Hairy cell leukemia.
  15. Monoclonal gammopathies (GM) GM of undetermined significance, multiple myeloma, Waldenstrom's macroglobulinemia.
  16. Hodgkin's disease.
  17. Malignant non-Hodgkin lymphoma.
  18. Therapy with differentiation inducing agents in hematology.
  19. Treatment with interferons in the blood-oncology.
  20. Allo- and autologous bone marrow in hematologic diseases: principles and guidelines.
  21. Bleeding diseases of platelet cause.
  22. Hemophilia and von Willebrand disease.
  23. Disseminated intravascular coagulation syndrome.
  24. Trombohemolitica thrombocytopenic purpura.

BIBLIOGRAPHY :

"Patologia Hematologica"."Hematology Pathology" Under the redaction of Professor Anca Roxana Lupu MD.University Publishing House Carol Davila 2007, 169 pag.

„Hematologie clinica"  "Clinical Hematology" – Professor Delia Mut Popescu MD. ─ 2nd Edition . - Bucharest : Medical Publishing House, 2003 (Universul) 336 p. - (Courses ).2004/28a.

„Hematologie Clinica" "Clinical Hematology" „–Ljubomir Petrov , Andrei Cucuianu, Anca Bojan ,Laura Urian- Cluj Napoca Casa Cartii de Stiinta , 2009-400pag

  • hematology
  • hematological malignancies
  • bone marrow transplantation
  • laboratory
  • clinical research
  1. The expression of molecules associated with cell signal and gene rearrangements - molecular markers identified in clonal B cell lymphoproliferative development. Establishment of national registry of follicular lymphoma" –PN II -41-093- chief of proiect
  2. Integration of cytogenetic and molecular biology techniques in the diagnosis of tumor-splenomegaly ethiopatogenic and prognostic implications. CEEX, chief of proiect, Contract No. 96
  3. Addressing complex cellular, molecular and genetic aspects of new pathogenic mechanisms in malignant myeloproliferations.Project Partner 111 CEEX
  4. Study of hemostasis disorders in multiple trauma with development and implementation of an algorithm for diagnosis and treatment in intensive care units in Romania in order to reduce mortality and morbidities. Project Partner, contract No.193 / 2006. CEEX
  5. Molecular monitoring of BCR-ABL hybrid oncogene in chronic myeloid leukemia (CML) REAL-TIME quantitative PCR; founding of a national registry for patients with LMC; PN II-41-087-Project Partner
  6. Vascularized bone marrow transplantation as a microsurgical method replacing conventional bone marrow cells transplantation in the treatment of hematologic disorders;  PN II 42-174
  • "Patologia Hematologica"."Hematology Pathology" Under the redaction of Professor Anca Roxana Lupu MD.University Publishing House Carol Davila 2007, 169 pag.
  • Acquired von Willebrand disease: from theory to practice. Andrei Colita, Carmen E~aguna, Andra Costache, Gabriela Borsaru, Raluca Manolache, Ana Maria Ivanescu, Anca Roxana Lupu. Revista Romana de Medicinade Laborator / Romanian Laboratory Medicine Magazine –vol. 24/2016 IF – 0,239
  • Association of "cup-like" blasts morphology with NPM1 mutation in acute myeloid leukemia. Berbec N, Lupu AR, Angelescu S, Mandescu D, Bari M Rev Romana Med Lab / Romanian Laboratory Medicine Magazine. 2015;23(2):240-3. DOI:10.1515/rrlm-2015-0021 (IF=0,239)
  • Molecular characterization of complex chromosomal changes in de novo acute myeloid leukemia: a case report. Nicoleta P. Berbec, Sorina M.F. Papuc, Andreea C.D.F. Tutulan-Cunita, Silvana M. Angelescu, Anca I. Lupu, Aurora A. Arghir Revista Romana de Medicina de Laborator/ Romanian Laboratory Medicine Magazine, nr.1, 2013 DOI: 2478/rrlm-2013-0018 (IF=0,171)
  • Value of Multifaced Approach Diagnosis and Classification of Acute Leukemias. Silvana ANGELESCU, Nicoleta Mariana BERBEC, Andrei COLITA, Doina BARBU, Anca Roxana LUPU - Maedica A Journal of Clinical Medicine, vol., 2012 ISSN: 1841-9038 indexed at PubMed | EBSCO, CNCSIS B+
  • Combined procedure of vascularized bone marrow transplantation and mesenchymal stem cells graft–An effective solution for rapid hematopoietic reconstitution and …A Colita, A Colita D Zamfirescu, AR Lupu - Medical hypotheses, 2012 - Elsevier
  • Relationship between chromosomal changes complexity and disease aggressiveness in myeloid and lymphoid disorders. A. Lungeanu, A. Arghir, A. Lupu, D. Mut-Popescu, N. Berbec. J. Cell. Mol. Med., vol. 6, no. 3,389-398, july-september 2002. (IF=1,694) doi: 10.1111/j.1582-4934.2002.tb00517.x
  • Abnormalities of platelet aggregation in chronic myeloproliferative disorders. Simona Avram, Anca Lupu, Silvana Angelescu, Nicoleta Olteanu and Delia Mut-Popescu*Journal of Cellular and Molecular Medicine (ISI), Volume 5, Issue 1, pages 79–87, January 2001 doi: 10.1111/j.1582-4934.2001.tb00140

University of Medicine and Pharmacy "Carol Davila" Bucharest

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Dionisie Lupu Street, no. 37, Sector 2, Bucharest

Fiscal code: 4192910
bank account: RO57TREZ70220F330500XXXX
Bank: Sector 2 Treasury

Phone:
+4021 3180719
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